Table I. Genes whose activation by tunicamycin treatment is attenuated in xbp-1(zc12)III mutant animals.
| Gene | Induction in N2 | Induction in xbp-1 | Protein |
|---|---|---|---|
| F43E2.8 | 1.92 ± 0.14 | 0.44 ± 0.25 | HSP-4 |
| C15H9.6 | 1.32 ± 0.06 | 0.68 ± 0.05 | HSP-3 |
| T27E4.8 | 2.85 ± 0.30 | 0.18 ± 0.37 | HSP-16 |
| Y46H3A.E | 2.67 ± 0.34 | 0.49 ± 0.40 | HSP16-41 |
| Y46H3A.D | 2.55 ± 0.48 | −0.20 ± 0.17 | HSP16-2 |
| T27E4.2 | 2.48 ± 0.22 | 0.29 ± 0.41 | HSP-16 |
| T27E4.9 | 1.97 ± 0.08 | −0.57 ± 0.32 | HSP16-49 |
| C12C8.1 | 2.08 ± 0.15 | 0.54 ± 0.17 | Member of the heat shock HSP70 protein family |
| T14G8.3 | 1.35 ± 0.05 | −0.17 ± 0.13 | HSP70-like ATPase |
| C14B9.2 | 1.83 ± 0.16 | 0.19 ± 0.15 | Member of the protein disulfide isomerase protein family |
| C07A12.4 | 1.38 ± 0.10 | 0.42 ± 0.17 | PDI-2 |
| B0403.4 | 1.66 ± 0.12 | 0.46 ± 0.10 | Member of the thioredoxin protein family |
| C53B4.7 | 2.28 ± 0.44 | −0.09 ± 0.14 | Putative GDP-mannose 4,6-dehydratase |
| Y41C4A.11 | 3.27 ± 0.21 | −0.40 ± 0.13 | Member of the WD repeat protein family |
| F45E4.1 | 3.05 ± 0.34 | 0.67 ± 0.15 | ARL-6 |
| F20D1.5 | 2.80 ± 0.51 | 0.68 ± 0.20 | ARL-7 |
| B0285.9 | 3.50 ± 0.30 | −0.28 ± 0.11 | Member of the choline/ethanolamine kinase protein family |
| K01D12.11 | 4.21 ± 0.31 | 0.85 ± 0.13 | Member of the GST protein family |
| C55B6.2 | 1.85 ± 0.17 | 0.29 ± 0.14 | Putative orthologue of human protein kinase inhibitor p58 |
| ZK662.4 | 3.10 ± 0.31 | 0.67 ± 0.02 | Negative regulator of the LET-23 receptor tyrosine kinase LIN-15 |
| F20D6.4 | 2.69 ± 0.10 | 0.04 ± 0.31 | SRP-7, serine protease inhibitor |
| B0222.9 | 2.05 ± 0.20 | 1.00 ± 0.08 | Similar to xanthine dehydrogenase |
| Y40B10A.G | 1.40 ± 0.13 | 0.27 ± 0.16 | Similar to O-methyltransferase |
| R07B1.10 | 1.34 ± 0.10 | 0.19 ± 0.09 | Member of the galectin family |
| F41B4.3 | 2.86 ± 0.45 | 0.06 ± 0.09 | Unknown |
| K02D7.4 | 1.70 ± 0.05 | 0.38 ± 0.14 | Unknown |
Shown is the mean ± SEM (n = 3) of the base2 log–fold increase in tunicamycin-treated animals over untreated animals for each genotype. The induction of lin-15 (ZK662.4) is likely to be an artifact of the hsp-4::gfp;lin-15 array present in both wild-type and mutant animals.