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. 2002 Aug 19;158(4):719–729. doi: 10.1083/jcb.200202124

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — Heterozygote, 4-mo-old mouse CNS, expressing wild-type and null alleles of the Plp gene, immunostained for PLP/DM20. (A) Ventral column of spinal cord to show mosaic of wild-type myelin (positively stained) and myelin formed by oligodendrocytes expressing a null allele (no staining); the former predominate. (B) Optic nerve to show mosaic of positive and negative sheaths in conjunction with patches predominantly of one immunotype. Bars: (A) 20 μm; (B) 50 μm.