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. 2002 Feb 18;156(4):751–760. doi: 10.1083/jcb.200105147

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Copyright © 2002, The Rockefeller University Press

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Figure 8. — Number and diameter of muscle fibers. (A) The number of muscle fibers increased significantly only in gracilis anterior muscle and not gracilis posterior or soleus muscles. (B) The average fiber area increased significantly in gracilis posterior muscle and in IGF-EX gracilis anterior muscle only. Singly innervated muscles therefore respond to hypertrophic signals by increasing average fiber area and not number. Gracilis anterior muscle, which contains intrafascicularly terminating fibers, responds to hypertrophic signals by increasing the number of muscle fibers in cross-section.