Table 3.
GO annotation of genes according to growth rate response
| Slope >1.5 SDs below average | 337 genes | |||
| Process | p value | Gene hits | Term size | Term fraction (%) |
| Fatty acid β-oxidation | 1.80E-04 | 6 | 8 | 75.0 |
| Glutamine family amino acid catabolic process | 4.20E-04 | 7 | 13 | 53.8 |
| Energy reserve metabolic process | 2.61E-05 | 12 | 36 | 33.3 |
| Glucose metabolic process | 8.10E-04 | 14 | 65 | 21.5 |
| Monosaccharide metabolic process | 1.10E-04 | 18 | 92 | 19.6 |
| Hexose metabolic process | 9.50E-04 | 16 | 85 | 18.8 |
| Cellular carbohydrate metabolic process | 7.75E-12 | 40 | 213 | 18.8 |
| Monocarboxylic acid metabolic process | 5.86E-06 | 23 | 124 | 18.5 |
| Carbohydrate metabolic process | 1.37E-12 | 43 | 233 | 18.5 |
| Energy derivation by oxidation of organic compounds | 4.59E-06 | 25 | 143 | 17.5 |
| Generation of precursor metabolites and energy | 5.02E-07 | 30 | 181 | 16.6 |
| Coenzyme metabolic process | 1.40E-04 | 22 | 135 | 16.3 |
| Alcohol metabolic process | 2.80E-04 | 24 | 163 | 14.7 |
| Carboxylic acid metabolic process | 6.52E-05 | 37 | 312 | 11.9 |
| Organic acid metabolic process | 6.52E-05 | 37 | 312 | 11.9 |
| Function | ||||
| Oxidoreductase activity | 1.50E-07 | 38 | 270 | 14.1 |
| Component | ||||
| Peroxisomal matrix | 1.45E-06 | 8 | 12 | 66.7 |
| Microbody | 3.53E-05 | 14 | 57 | 24.6 |
| Peroxisome | 3.53E-05 | 14 | 57 | 24.6 |
| Slope >1.5 SDs above average | 291 genes | |||
| Process | ||||
| Protein import into mitochondrial matrix | 1.00E-07 | 11 | 22 | 50.0 |
| Maturation of SSU-rRNA | 1.68E-10 | 17 | 44 | 38.6 |
| Protein import into mitochondrion | 4.67E-07 | 13 | 37 | 35.1 |
| Protein targeting to mitochondrion | 2.23E-05 | 13 | 49 | 26.5 |
| Mitochondrial transport | 6.11E-05 | 14 | 62 | 22.6 |
| Ribosome biogenesis and assembly | 4.73E-15 | 57 | 402 | 14.2 |
| Ribonucleoprotein complex biogenesis and assembly | 2.20E-12 | 58 | 473 | 12.3 |
| Translation | 8.47E-19 | 83 | 686 | 12.1 |
| rRNA metabolic process | 8.51E-05 | 29 | 247 | 11.7 |
| rRNA processing | 1.60E-04 | 28 | 240 | 11.7 |
| Macromolecule biosynthetic process | 1.16E-19 | 97 | 881 | 11.0 |
| Function | ||||
| snoRNA binding | 5.52E-06 | 11 | 32 | 34.4 |
| Structural constituent of ribosome | 3.72E-43 | 71 | 230 | 30.9 |
| Protein transporter activity | 2.10E-04 | 12 | 53 | 22.6 |
| Structural molecule activity | 3.34E-30 | 72 | 357 | 20.2 |
| Component | ||||
| Mitochondrial outer membrane translocase complex | 2.04E-05 | 6 | 8 | 75.0 |
| Cytosolic large ribosomal subunit (sensu Eukaryota) | 3.72E-25 | 37 | 97 | 38.1 |
| Cytosolic small ribosomal subunit (sensu Eukaryota) | 1.27E-15 | 24 | 64 | 37.5 |
| Cytosolic ribosome (sensu Eukaryota) | 1.02E-43 | 64 | 176 | 36.4 |
| Cytosolic part | 2.36E-41 | 65 | 197 | 33.0 |
| Large ribosomal subunit | 8.13E-26 | 44 | 142 | 31.0 |
| Ribosomal subunit | 4.18E-44 | 73 | 240 | 30.4 |
| Small ribosomal subunit | 7.37E-16 | 29 | 98 | 29.6 |
| Ribosome | 9.44E-38 | 80 | 357 | 22.4 |
| Small nucleolar ribonucleoprotein complex | 3.39E-07 | 23 | 132 | 17.4 |
| Nucleolar part | 4.92E-10 | 31 | 179 | 17.3 |
| Ribonucleoprotein complex | 1.10E-35 | 101 | 623 | 16.2 |
| Nucleolus | 1.44E-10 | 42 | 304 | 13.8 |
| Nonmembrane-bound organelle | 1.96E-27 | 118 | 1033 | 11.4 |
| Intracellular non-membrane-bound organelle | 1.96E-27 | 118 | 1033 | 11.4 |
| Cytosol | 2.69E-13 | 69 | 626 | 11.0 |
| Unresponsive genes | 980 genes | |||
| Process | ||||
| 80 biological processes | <1.00E-03 | >10.0 | ||
| Function | ||||
| Exoribonuclease activity, producing 5′-phosphomonoesters | 6.60E-04 | 13 | 23 | 56.5 |
| Exoribonuclease activity | 6.60E-04 | 13 | 23 | 56.5 |
| Exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5′-phosphomonoesters | 8.10E-04 | 15 | 30 | 50.0 |
| Guanyl-nucleotide exchange factor activity | 7.40E-04 | 17 | 37 | 45.9 |
| General RNA polymerase II transcription factor activity | 6.19E-05 | 25 | 62 | 40.3 |
| GTPase regulator activity | 5.50E-04 | 27 | 77 | 35.1 |
| RNA polymerase II transcription factor activity | 4.90E-04 | 37 | 123 | 30.1 |
| Transcription regulator activity | 2.01E-09 | 90 | 327 | 27.5 |
| Protein binding | 1.40E-04 | 121 | 585 | 20.7 |
| Hydrolase activity | 1.61E-05 | 160 | 802 | 20.0 |
| Component | ||||
| ∼40 cellular components | <1.00E-03 | >10.0 | ||