Table 1.
Abl overexpression and Bcr-Abl misexpression cause embryonic lethality
| Driver | Transgene | % embryonic lethalitya | nb |
|---|---|---|---|
| e22-GAL4 | p185 (17) | 100 | 389 |
| p185 (6a1) | 78 | 343 | |
| p185-Y177F (14b) | 80 | 255 | |
| p210 (31) | 96 | 350 | |
| p210 (11a) | 56 | 355 | |
| p210 (6) | 64 | 348 | |
| P210 kinase dead (11a) | 8 | 347 | |
| P210 kinase dead (15a) | 2 | 361 | |
| Wild-type Abl (UA3) | 68 | 698 | |
| Kinase-dead Abl (UL6) | 8 | 366 | |
| arm-GAL4:VP16 | p185 (17) | 100 | 240 |
| p185 (6a1) | 100 | 319 | |
| P185-Y177F (14b) | 100 | 257 | |
| p210 (11a) | 96 | 309 | |
| p210 (11) | 100 | 298 | |
| P210 kinase dead (15a) | 8 | 333 | |
| Wild-type Abl (UA22) | 82 | 319 | |
| Wild-type Abl (UA3) | 100 | 328 | |
| Kinase-dead Abl (UL1) | 4 | 174 | |
| en-GAL4 | p185 (17) | 12 | 242 |
| p185 (6a1) | 12 | 238 | |
| p210 (31) | 12 | 464 | |
| Wild-type Abl (UA22) | 4 | 167 |
a Corrected for fraction of embryos of correct genotype. Both e22-GAL4 and arm-GAL4:VP16 are heterozygous, so only 50% of the embryos receive the driver and thus could be affected. Some of the transgenes were also maintained as balanced stocks and thus are also heterozygous.
b Number of embryos scored.