Table 2.

Disrupted genes conferring filamentous growth and glycerol growth phenotypes

Disrupted gene	Filamentous growtha	Growth on glycerol	Description
ATP14	−−	Inviable	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase
COA1	−	Inviable	Putative protein of unknown function; the authentic, nontagged protein is detected in highly purified mitochondria
FMC1	−−	Inviable	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase
FMP25	−	Inviable	Putative protein of unknown function; the authentic, nontagged protein is detected in highly purified mitochondria
FMP38	−	Inviable	Putative protein of unknown function; the authentic, nontagged protein is detected in highly purified mitochondria
IFM1	−−	Inviable	Mitochondrial translation initiation factor 2
MDJ1	−	Inviable	Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix
MDM30	−	Inviable	F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells
MEF2	−−	Inviable	Mitochondrial elongation factor involved in translational elongation
MGM101	−	Inviable	Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid
MHR1	−	Inviable	Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus
MMF1	−	Inviable	Mitochondrial protein involved in maintenance of the mitochondrial genome
MMM1	−−	Inviable	Mitochondrial outer membrane protein required for normal mitochondrial morphology and mitochondrial DNA stability
MST1	−−	Inviable	Mitochondrial threonyl-tRNA synthetase
MSW1	−−	Inviable	Mitochondrial tryptophanyl-tRNA synthetase
QCR9	−	Inviable	Subunit 9 of the ubiquinol cytochrome c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain
RIM1	−−	Inviable	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
RPO41	−	Inviable	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages
SUV3	−−	Inviable	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p
WHI2	−−	Inviable	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation
YOX1	−−	Inviable	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes in the promoters of cell cycle-regulated genes expressed in M/G1 phase
YDR133c	−−	Inviable	Uncharacterized open reading frame

^a −−, severe filamentous growth defect; −, intermediate filamentous growth defect.