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. 1999 Oct 18;147(2):375–388. doi: 10.1083/jcb.147.2.375

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Quantification of the effect of IG2 and α1-AP on neurite outgrowth on LN and BM. E6 retinal explants were cultured on either LN or BM with the amounts of antibody indicated below the bars. IG2 and α1-AP reduced the average length of axon outgrowth on BM in a dose-dependent fashion (A and C). IG2 also showed a significant effect on LN (B). No effect was observed for α1-AP on LN (D). To address the possibility of an effect induced by antibody cross-linking we used anti-NCAM as a control. No effect of 20 μg anti-NCAM was observed on either LN or BM (E and F). Anti-β-integrin JG22 was used as a comparison for IG2. On BM neurite outgrowth was affected in a dose-dependent manner by JG22 (E) while on LN outgrowth was almost completely blocked by an amount of 20 μg antibody (F). One datapoint represents a measurement of one retinal strip from an independent experiment performed with at least one retinal strip. Double asterisks indicate P < 0.0001.