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. 1999 Oct 18;147(2):295–306. doi: 10.1083/jcb.147.2.295

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Cells forced into premature mitosis by cyclin A often fail to condense fully their chromosomes. HeLa cells were synchronized in G2 phase and injected with 2–4 μM cyclin A/CDK2 as in Fig. 1 A. Representative DIC images are shown of a cell that does (A) and a cell that does not (B) fully condense its chromosomes at metaphase. The cell that does not condense its chromosomes divides but the daughter cells fuse.