Figure 2.
Cells forced into premature mitosis by cyclin A often fail to condense fully their chromosomes. HeLa cells were synchronized in G2 phase and injected with 2–4 μM cyclin A/CDK2 as in Fig. 1 A. Representative DIC images are shown of a cell that does (A) and a cell that does not (B) fully condense its chromosomes at metaphase. The cell that does not condense its chromosomes divides but the daughter cells fuse.