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. 1999 Oct 18;147(2):295–306. doi: 10.1083/jcb.147.2.295

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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p21N will cause a prophase cell to return to G2 phase. PtK₁ cells in prophase were microinjected with purified GST-p21N to a final concentration of 2–4 μM and visualized by time-lapse DIC microscopy. (A) PtK₁ cells just before microinjection at 13.20. The condensed chromosomes are clearly visible. (B) The same PtK1 cell 115 min after injection of p21N. The chromosomes have decondensed and the nucleolus has reformed. Images are representative of 17 cells in at least five independent experiments.