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. 1999 Dec 27;147(7):1419–1430. doi: 10.1083/jcb.147.7.1419

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Distribution of vinculin and F-actin in large megakaryocytes adherent to fibrinogen. Megakaryocytes from day 6 cultures were incubated for 45 min on fibrinogen-coated coverslips in the absence (A and C) or presence (B and D) of 100 nM phorbol myristate acetate. The cells were fixed, permeabilized and stained to visualize vinculin (green) and F-actin (red) by confocal microscopy. Each panel shows a 0.2-μm confocal image taken near the ventral surface of a representative cell. The arrowheads in D point to vinculin-rich focal adhesions, and the arrow points to actin stress fibers. This experiment is representative of three so performed. Bar, 10 μm.