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. 2000 Jan 24;148(2):385–397. doi: 10.1083/jcb.148.2.385

Figure 3.

Figure 3

Functional ErbB2 receptors are required for induction of carcinoma cell invasion of the ECM in response to EGF family peptides. A, MCF7 cells were serum-starved and allowed to invade Transwell membranes coated with the reconstituted basement membrane material Matrigel for 24 h in the presence or absence of 50 ng/ml of NDF, EGF, BTC (β-cell.), or 10% FBS as described in Materials and Methods. Each bar represents the mean ± SEM of at least three independent experiments. B, MCF7 cells with and without cell surface ErbB2 receptors (MCF7-5R) were serum-starved, then examined for their ability to invade the reconstituted basement membrane as described above in the presence or absence of 50 ng/ml of NDF or 10% FBS. Each bar represents the mean ± SEM of at least three independent experiments.