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. 2000 Jan 24;148(2):343–352. doi: 10.1083/jcb.148.2.343

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Antisense against Hox B3 impairs BM-induced capillary morphogenesis in EC. A, Western blot for Hox B3 in 50 μg total protein lysates from immortalized HMEC-1 stably transfected with empty vector (control) or plasmid expressing antisense against human Hox B3 (Hox B3 AS). B, Capillary morphogenesis of HMEC-1 after culturing on thick BM (Matrigel) after 18 h. The panel on the left shows normal capillary morphogenesis occurring in HMEC-1 stably transfected with empty vector (Control). The panel on the right shows impaired capillary morphogenesis in HMEC-1 transfected with antisense against Hox B3 (Hox B3 AS). The arrow shows representative groups of cells that remain in clusters and fail to elongate and form contacts with adjacent cells.