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. 2000 Mar 20;148(6):1165–1176. doi: 10.1083/jcb.148.6.1165

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Genomic organization of the periplakin/ubinuclein locus on human chromosome 16p13.3. A, Sequencing of the human genomic P1 clone, GS14060, containing PPL disclosed the presence of a novel gene, UBN1. The orientation of each gene is shown on top, and the accession numbers for the DNA sequences available from the GenBank/EMBL/DDBJ are denoted in the middle. The exons drawn and placed in scale are shown as black squares. B, Human UBN1 and PPL genes were found to reside in tail-to-tail orientation. The distance between the corresponding polyadenylation signals (AATAAA and TTTATT, underlined) is 194 bp. The ends of the cDNAs are indicated by brackets. C, The DNA sequencing of a mouse genomic λ-clone revealed that the arrangement of the mouse Ubn1/Ppl locus on the syntenic region of mouse chromosome 16 was similar to that of the human locus, and the distance between the polyadenylation signals is 197 bp.