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. 2000 Mar 20;148(6):1295–1304. doi: 10.1083/jcb.148.6.1295

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The tPA^−/− mossy fiber sprouting phenotype can be reversed to that of wild-type mice by infusion of recombinant tPA. Sections of KA-injected wild-type (wt) and tPA^−/− mice are used as controls. When recombinant tPA (tPA^−/−/tPA) is infused into the hippocampus and the intraamygdala KA injection follows, the Timm-positive mossy fiber sprouting pattern is comparable to that of wild-type mice. However, infusion of catalytically inactive S478A tPA (tPA^−/−/S478A tPA) rescues only the neurite pathfinding through the supragranular region (arrowheads), but the aberrant laminar band (arrows) persists.