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Effect of exogenously loaded Tβ4 on the actin cytoskeleton of keratocytes, as judged from the phalloidin staining after the experiment. (A) Control (unloaded) keratocytes show meshwork of actin filaments in the lamella (marked 1) and parallel sarcomeric type of actin filaments in the perinuclear region (marked 2). (B) In Tβ4-loaded keratocytes, lack of these cytoskeletal features suggests Tβ4-induced actin filament depolymerization.
