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. 2001 May 28;153(5):999–1010. doi: 10.1083/jcb.153.5.999

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Cathepsin B plays a minor role in death receptor–induced apoptosis of primary cells. (A) The survival of hepatocytes pretreated with the indicated concentrations of CA-074-Me for 1 h before the addition of 200 nM actinomycin D plus 28 ng/ml of rmTNF or 100 ng/ml of anti-CD95 antibody (Jo-2) was analyzed after 22-h treatment by the LDH release assay. (B) MEF (passage 4) originating from wild-type, cathepsin B–, or cathepsin S–deficient mice were left untreated or treated with 50 μM CA-074-Me or 100 μM zFA-fmk for 1 h before an 18-h treatment with 100 ng/ml of rhTNF plus 10 μM cycloheximide. The survival was analyzed by the MTT assay. The values represent means of triplicate determinations ± SD. *p-value < 0.01, as compared with control cells.