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. 2000 Nov 27;151(5):1047–1056. doi: 10.1083/jcb.151.5.1047

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Association of Mcd1p with chromosomes in cell cycle arrested cultures. The immunoprecipitated DNA was quantified as a percent of the total lysate from HU (gray line, open circles) or nocodazole (black line, closed circles) arrested cultures. The amount of immunoprecipitated DNA (as percent of total) is plotted on the y axis versus DNA sequence coordinates on the x axis. (A) Cell cycle–dependent association of Mcd1p with CEN3 and flanking sequences. The middle fragment represents CEN3. The fold increase in binding in nocodazole arrested cells relative to HU arrested cells was tenfold or higher between different experiments. (B) Mcd1p binding to a part of the left arm of chromosome III in cell cycle arrested cells. (C) Comparison of Mcd1p binding to the entire RDN1 repeat in cell cycle arrested cells.