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UPIII-ablation induced hydronephrosis and kidney abnormalities. Paraffin sections (hematoxylin and eosin stained) of kidneys of normal (a, c, and e) and UPIII-depleted (b, d, and f) mice (2–3-mo old). (a and b) Low magnification view, (c and d) cortex, and (e and f) papilla. Note the expanded renal pelvic space and the dilation of the collecting ducts in the UPIII-depleted mice. C, cortex; MD, medulla; P, papilla; and RP, renal pelvis. Bar: 1 mm (a and b) and 50 μm (e and f).
