Figure 1.
Experimental design. Twenty animals were treated with MPTP (an average of 3.1 mg/kg for each monkey; described in text). According to baseline severity in the last month prior to transplantation, animals were randomly allocated into 4 groups to receive small solid pieces (less than 1 mm × 1 mm × 1 mm) or cell suspensions from monkey fetal VM, either in the caudate or the putamen targets. One week after transplantation parkinsonism and normal behavior were evaluated 5 days/week for 9 months. After these 9 months animals were perfused for histological evaluation.