Table 1.
Effects of selected EDC tested in thyroid-relevant in vitro assays.
| Compound | Iodide uptake | TPO activity | TR agonist | TR antagonist | T4 binding to TTR |
|---|---|---|---|---|---|
| 4-MBC | ↓ | — | ND | ND | ND |
| 4-NP | ↓ | ↓ | ↑ | ↓ | ND |
| Adiol | ↓ | — | ND | ND | ND |
| BPA | — | ↓ | ND | ND | ND |
| BP2 | — | ↓ | ↑ | — | ND |
| BP3 | — | — | ↑ | — | ND |
| Daidzein | ND | ND | ND | ND | ↓ |
| Dibutylphthalate | — | — | ND | ND | ND |
| E2 | ↓ | — | ND | ND | ND |
| F21388 | ND | ↓ | ND | ND | ND |
| Genistein | ↓ | ↓ | ↑ | — | ↓ |
| Glycitein | ND | ND | ND | ND | ↓ |
| Linuron | — | — | ↑ | — | ND |
| OMC | ↓ | — | ↑ | — | ND |
| Procymidon | — | — | ND | ND | ND |
| Resveratrol | — | ↓ | ↑ | — | ND |
| Silymarin | — | ↓ | ↑ | — | ND |
| Xanthohumol | ↑ | — | ND | ND | ND |
Abbreviations: ↑, stimulatory or agonistic effect; ↓, inhibitory or antagonistic effect; —, no effect; ND, not determined.