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Micronucleus-forming activity of PhIP with or without lindane. Cell suspensions (3 mL, ~ 1 × 104 cells) in 30-mm petri dishes were prepared and treated in the CBMN assay as described in “Materials and Methods.” Micronucleus formation was scored in 1,000 binucleate cells. (C) Number of MNi in binucleate MCF-7 cells were scored from 1 to 5, with 5 representing the maximum score for this study.
