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. Author manuscript; available in PMC: 2008 Jan 3.
Published in final edited form as: Nat Neurosci. 2006 Dec 17;10(1):87–92. doi: 10.1038/nn1818

Figure 5.

Figure 5

Effect of severing tip links on hair-bundle motion. (a) Measurements from the opposite edges of a quiescent hair bundle portray the enhanced thermal motion after destruction of the tip links and other interstereociliary filaments by BAPTA. (b) The cross-correlations before and after the treatment document the altered correlation time of the bundle’s motion. Severing the connections between stereocilia softened the hair bundle, thereby increasing the inversely related time constant for mechanical relaxation. The peak cross-correlation in 20 records was 0.97 ± 0.02, to be compared with 0.89 ± 0.03 over 19 records for the same bundle prior to treatment. (c) The coherency spectrum averaged across 11 measurements taken from four cells treated with BAPTA confirms the strong correlation between the movements of the bundles’ opposite edges. (d) The control spectrum for measurements from the same edges of the hair bundles differs negligibly from that in (c).