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. 2007 Oct 15;8:372. doi: 10.1186/1471-2164-8-372

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Copyright © 2007 Imamura et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Upstream blocks conserved beyond neutral expectations among P. falciparum and the three mouse malaria species. These blocks were identified by searching the aligned regions upstream of orthologous genes and are strong candidates for having novel functions. These are (A) at 275 bp upstream of PF14_0091, a hypothetical gene, (B) at 81 bp upstream of PF14_0682, a hypothetical gene, (C) at 185 bp upstream of PF14_0212, a hypothetical gene, (D) at 275 bp upstream of PF14_0437, a helicase truncated putative gene, and (E) at 1 bp upstream of PFA0400c, a beta3 protesome putative gene. In total, we observe 81 P. falciparum 5' regions with a conservation p-value of 10^-6or lower.