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. 2000 Mar 6;148(5):1047–1062. doi: 10.1083/jcb.148.5.1047

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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SdpI and -II induce a striking cortical actin phenotype upon overexpression. HeLa cells transiently transfected with SdpI full-length (a, b, c, and d), SdpII-l (e and f), and SdpII-s (g and h) (green fluorescence) exhibit actin microspikes (filopodia) all over the cell surfaces in addition to protrusion-like structures (lamellipodia). This overexpression phenotype was only observed in transfected cells, untransfected cells were unaffected and displayed smooth cell surfaces. Right panels show phalloidin–Texas red staining of F-actin to visualize actin rearrangements. Antitag labeling to identify syndapin-overexpressing cells is shown in the left panels. Bar: (a, b, e–h) 25 μm; (c and d) 15.75 μm.