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Models for microtubule tip localization. A protein specifically localized to the ends of growing microtubules could bind to tubulin heterodimers and copolymerize into the microtubule (A), or recognize a specific conformation at the growing microtubule end, such as the GTP cap or the unrolled sheet (B). Dissociation from the microtubule could result from exclusion as the protofilament seam closes or from the tension caused by seam closure.
