Figure 2.

Tibial growth plate histomorphometry of collagen X Tg and KO mice. A, H&E sections of day 21 tibial metaphyses of wild-type (control), and collagen X KO and Tg mice with mild (KO, TG) and acute (KO MUT, TG MUT) phenotypes. GP, Growth plate; PC, proliferating cartilage; HC, hypertrophic cartilage; T, trabecular bone; M, marrow. Note: less pronounced overall compression of growth plates in KO mice as that in TG mice; trabecular reduction in both KO and TG mice; more severe growth plate compressions and trabecular reductions in both KO MUT and TG MUT; and erythrocyte predominance and leukocyte depletion in marrows of both KO MUT and TG MUT mice. Bar, 100 μm. B, Histomorphometric analysis of growth plate zones including overall growth plate width (overall), and widths of proliferative and hypertrophic cartilages. Note greater compressions of the proliferative zone in KO mice, and greater compressions of the hypertrophic zone in Tg mice. n, Sample number; error bars = standard error.