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. 2000 May 15;149(4):983–993. doi: 10.1083/jcb.149.4.983

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Histology and immunohistochemistry of longitudinal sections of thymus showing the cortex (C)/medulla (M) junction from week three wild-type (control) and collagen X KO mice with perinatal lethality (KO MUT). In the KO MUT, H&E staining reveals reduction of cortex and a paucity of cortical T cells, whereas TPE antibodies localize the cortex as a narrow strip compared with the extensive matrix in the control. Likewise, CD4 and CD8 T cell surface markers confirm a depletion of CD4⁺/CD8⁺ immature cortical lymphocytes in the KO MUT. Bar, 100 μm.