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. 2000 May 15;149(4):901–914. doi: 10.1083/jcb.149.4.901

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Model, describing endocytic organelles as a mosaic of membrane domains. The domain distribution of the three Rab proteins presented in this study, Rab4, Rab5, and Rab11 is depicted in red, green, and blue, respectively. Compartmentalization is achieved by dynamic functional arrangements of these domains, combinations of Rab4 and Rab5, and Rab4 and Rab11 being the most abundant. Arrows indicate direction of transferrin recycling. Cargo enters the cell via mainly Rab5-containing structures. Fast recycling is achieved by rapid sorting from Rab5 into Rab4-positive domains on the same endosome. Recycling slows down once transferrin enters pericentriolar membranes dominated by Rab4 and Rab11 domains.