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. Author manuscript; available in PMC: 2008 Jan 4.
Published in final edited form as: J Immunol. 2006 Nov 1;177(9):6548–6559. doi: 10.4049/jimmunol.177.9.6548

FIGURE 1.

FIGURE 1

MART-1-reactive TIL clones derived from several patients display a wide diversity of peptide and MART-1 tumor reactivities. A, IFN-γ production by 24 MART-1 clones derived from five patients, coincubated with titered MART-1 peptide on T2 target cells. B, IFN-γ response of MART-1 clones following coculture with MART-1/HLA-A*0201-positive (mel526+, mel624+) and HLA-A*0201-negative melanoma tumors (mel888−, mel938−). IFN-γ release was evaluated from 18-h culture supernatant by ELISA. C, Correlation of IFN-γ produced by each clone in response to coculture with T2 cells pulsed with MART-1 peptide or mel624+ MART-1-expressing tumor. D, Correlation of IFN-γ produced by each clone in response to coculture with two different MART-1/HLA-A*0201-expressing tumors. Statistical analysis by ANOVA regression analysis.