Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Dec 4;3:147. doi: 10.1038/msb4100189

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation or the creation of derivative works without specific permission.

PMC Copyright notice

Aging genes and interface genes are important to network stability. (A) Attacking the aging genes in the NP network increases the CPL of the network more rapidly than attacking randomly selected non-aging genes or removal of random nodes (‘failure'), but slower than specific attacks on hubs. Degree-matched attacks on aging and non-aging genes in the NP network are shown in the inset. (B) Attacking aging genes belonging to the NP network increases CPL of the HPRD network more rapidly than attacking aging genes not in the NP network or random removal of genes in the HPRD network. Degree-matched attacks on NP and non-NP aging genes in the HPRD network are shown in the inset. (C) Attacking the aging (or all) genes on the module interfaces increases CPL of the NP network more rapidly than attacking their counterparts in the cores. Degree-matched attacks on the core and interface genes are shown in the inset. Only the first 2% of the attacks are shown in the inset for the interface and core genes, the trend continues for the rest.