Table 1.

Statistical significance of age-related gene expression changes of the human brain and the fly modules

Module	Slope	P-value	R square	Spearman correlation	P-value	Condition
D	−0.353	5.16E−02	0.13	−0.37	4.25E−02	Human brain (entire period)
P	0.693	4.19E−01	0.02	0.10	6.06E−01
PP	−2.327	1.71E−02	0.19	−0.33	7.83E−02
I	0.900	1.95E−02	0.18	0.40	2.82E−02
D	−0.582	1.90E−02	0.23	−0.46	2.22E−02	Human brain first period (age⩽85 years)
P	2.661	2.04E−02	0.22	0.39	5.77E−02
PP	−0.429	6.82E−01	0.01	−0.12	5.83E−01
I	1.366	1.77E−02	0.23	0.46	2.44E−02
D	1.355	5.08E−01	0.09	0.56	1.92E−01	Human brain second period (age⩾85 years)
P	−10.220	2.09E−01	0.29	−0.83	2.12E−02
PP	−19.511	5.64E−02	0.55	−0.77	4.08E−02
I	4.079	6.71E−03	0.8	0.83	2.12E−02
D	−0.003	1.31E−03	0.3	−0.53	1.74E−03	Fly normal condition (7∼47 days)
P	0.003	4.81E−03	0.24	0.47	7.17E−03
O	−0.009	4.06E−12	0.8	−0.88	1.00E−06
R	0.012	6.66E−16	0.89	0.94	1.00E−06
D	0.001	3.70E−01	0.07	0.21	4.71E−01	Fly CR first half life span (age<40 days)
P	−0.004	9.21E−02	0.22	−0.31	2.86E−01
O	−0.005	6.70E−04	0.63	−0.47	9.13E−02
R	0.005	5.27E−04	0.65	0.81	4.80E−04
D	−0.004	4.54E−05	0.52	−0.73	3.50E−05	Fly CR last half life span (age⩾40 days)
P	0.005	1.90E−03	0.35	0.55	4.14E−03
O	−0.005	5.42E−06	0.6	−0.79	2.86E−06
R	0.006	2.24E−04	0.45	0.64	5.23E−04