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. 2007 Dec 4;3:147. doi: 10.1038/msb4100189

Table 2.

Significance of changes in C. elegans lifespan upon RNAi knockdown of testing and control genes

Group Gene name Human orthorlog P-value 1 % change in lifespan 1 P-value 2 % change in lifespan 2 Module
Testing genes R06A10.2a GNAS 0 −82.46 0 −84.83 PP interface
  Y40B1A.4a SP3 1.20E−12 −20.07 5.42E−12 −28.35 P core
  F43C1.2Ba MAPK1 0.00366 −14.23 0.0103b −8.24 D interface
  T20B12.2a TBP 9.66E−15 −26.88 3.19E−11 −15.31 D interface
  Y47D3A.29a POLA 0 −25.68 2.55E−15 −18.69 D interface
  Y54G9A.6 BUB3 0.027 +5.78 0.0497 +7.09 P interface
  ZK177.6a CDC20 5.11E−15 +32.43 0.000342 +17.19 D interface
  R03D7.4a TCEB3 0.00282 +8.73 0.000011 +16.74 D interface
  Y38F1A.10a PAK3 1.72E−08 +21.22 5.32E−13 +28.91 D interface
Control genes F26A3.2a NCBP2 6.40E−07 −22.79 1.11E−08 −25.27  
  Y51H1A.5 HDAC10 0.917 +1.58 0.149 −3.36  
  K10D2.7 MOCS2 0.0316 +11.09 0.434 −1.00  
  C04G2.6 KIAA1008 0.0212 −7.82 0.00301 −13.12  
  Y41E3.7 ACBD3 0.608 +3.74 0.255 −2.00  
  F45F2.2 HIST2H2BE 0.0633 −2.91 0.0861 −1.08  
  W09B12.1 ACHE 0.607 +0.11 0.0423 −8.10  

aAfter the gene names denote that RNAi of the genes significantly extend (shorten) C. elegans lifespan (P<0.01 for both duplicate experiments).

bA third time repeat gives rise to a more significant P-value, 2.68E-009.

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