Table 2.
Significance of changes in C. elegans lifespan upon RNAi knockdown of testing and control genes
Group | Gene name | Human orthorlog | P-value 1 | % change in lifespan 1 | P-value 2 | % change in lifespan 2 | Module |
---|---|---|---|---|---|---|---|
Testing genes | R06A10.2a | GNAS | 0 | −82.46 | 0 | −84.83 | PP interface |
Y40B1A.4a | SP3 | 1.20E−12 | −20.07 | 5.42E−12 | −28.35 | P core | |
F43C1.2Ba | MAPK1 | 0.00366 | −14.23 | 0.0103b | −8.24 | D interface | |
T20B12.2a | TBP | 9.66E−15 | −26.88 | 3.19E−11 | −15.31 | D interface | |
Y47D3A.29a | POLA | 0 | −25.68 | 2.55E−15 | −18.69 | D interface | |
Y54G9A.6 | BUB3 | 0.027 | +5.78 | 0.0497 | +7.09 | P interface | |
ZK177.6a | CDC20 | 5.11E−15 | +32.43 | 0.000342 | +17.19 | D interface | |
R03D7.4a | TCEB3 | 0.00282 | +8.73 | 0.000011 | +16.74 | D interface | |
Y38F1A.10a | PAK3 | 1.72E−08 | +21.22 | 5.32E−13 | +28.91 | D interface | |
Control genes | F26A3.2a | NCBP2 | 6.40E−07 | −22.79 | 1.11E−08 | −25.27 | |
Y51H1A.5 | HDAC10 | 0.917 | +1.58 | 0.149 | −3.36 | ||
K10D2.7 | MOCS2 | 0.0316 | +11.09 | 0.434 | −1.00 | ||
C04G2.6 | KIAA1008 | 0.0212 | −7.82 | 0.00301 | −13.12 | ||
Y41E3.7 | ACBD3 | 0.608 | +3.74 | 0.255 | −2.00 | ||
F45F2.2 | HIST2H2BE | 0.0633 | −2.91 | 0.0861 | −1.08 | ||
W09B12.1 | ACHE | 0.607 | +0.11 | 0.0423 | −8.10 |
aAfter the gene names denote that RNAi of the genes significantly extend (shorten) C. elegans lifespan (P<0.01 for both duplicate experiments).
bA third time repeat gives rise to a more significant P-value, 2.68E-009.