Table 2.

Significance of changes in C. elegans lifespan upon RNAi knockdown of testing and control genes

Group	Gene name	Human orthorlog	P-value 1	% change in lifespan 1	P-value 2	% change in lifespan 2	Module
Testing genes	R06A10.2a	GNAS	0	−82.46	0	−84.83	PP interface
	Y40B1A.4a	SP3	1.20E−12	−20.07	5.42E−12	−28.35	P core
	F43C1.2Ba	MAPK1	0.00366	−14.23	0.0103b	−8.24	D interface
	T20B12.2a	TBP	9.66E−15	−26.88	3.19E−11	−15.31	D interface
	Y47D3A.29a	POLA	0	−25.68	2.55E−15	−18.69	D interface
	Y54G9A.6	BUB3	0.027	+5.78	0.0497	+7.09	P interface
	ZK177.6a	CDC20	5.11E−15	+32.43	0.000342	+17.19	D interface
	R03D7.4a	TCEB3	0.00282	+8.73	0.000011	+16.74	D interface
	Y38F1A.10a	PAK3	1.72E−08	+21.22	5.32E−13	+28.91	D interface
Control genes	F26A3.2a	NCBP2	6.40E−07	−22.79	1.11E−08	−25.27
	Y51H1A.5	HDAC10	0.917	+1.58	0.149	−3.36
	K10D2.7	MOCS2	0.0316	+11.09	0.434	−1.00
	C04G2.6	KIAA1008	0.0212	−7.82	0.00301	−13.12
	Y41E3.7	ACBD3	0.608	+3.74	0.255	−2.00
	F45F2.2	HIST2H2BE	0.0633	−2.91	0.0861	−1.08
	W09B12.1	ACHE	0.607	+0.11	0.0423	−8.10

^aAfter the gene names denote that RNAi of the genes significantly extend (shorten) C. elegans lifespan (P<0.01 for both duplicate experiments).

^bA third time repeat gives rise to a more significant P-value, 2.68E-009.