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Model for the roles that Cdc42 and Rac play in stimulating exocytosis of secretory granules in RBL-2H3 cells. Upon antigen stimulation, Cdc42 and/or Rac activate at least three processes that are required for degranulation: (a and b) stimulation of calcium signaling and PKC activation, (c) actin cytoskeletal remodeling, and (d) an as yet unidentified function subsequent to calcium influx during the later stages of degranulation.
