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. 2000 May 29;149(5):1157–1166. doi: 10.1083/jcb.149.5.1157

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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tPA is produced by Schwann cells after sciatic nerve crush. Immunocytochemistry with an antibody against tPA on longitudinal cryostat sections of wild-type, uninjured sciatic nerve revealed tPA staining only of the sciatic nerve vasculature (A). As early as 2 d after crush (cd2) tPA immunoreactivity was increased in the endoneurium (B). Sciatic nerve from a tPA^−/− mouse showed no immunoreactivity with the tPA antibody (C). Immunostaining of parallel sections of a wild-type sciatic nerve 2 d after crush showed similar morphology between tPA immunoreactive cells (D) and GFAP-positive Schwann cells (E). The number of GFAP-positive cells was equivalent in wild-type and tPA^−/− nerves before and after crush, suggesting that the number of Schwann cells is not significantly different in the two genotypes. Bar: (A–C) 93 μm; (D–E) 18 μm.