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CCT is down-regulated after stroke, impeding PC synthesis. CDP-choline liposomes deliver the drug intact to the brain, bypassing the CCT step. CCT: cytidine triphosphate:phosphocholine cytidylyltransferase. CPT: CDP-choline:1,2-diacylglycerol cholinephosphotransferase. The Western blot shows loss of CCT protein after stroke.
