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. 2000 Apr 3;149(1):13–16. doi: 10.1083/jcb.149.1.13

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Schematic drawing of TJs. At the most apical region of lateral membranes, TJs occur between two adjacent cells. TJs are composed of paired TJ strands, in which each TJ strand laterally and tightly associates with that in the apposing membrane of adjacent cells. Paired TJ strands are thought to contain aqueous pores. In transcellular and paracellular pathways, materials move across plasma membranes and TJs, respectively.