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. 2000 Jun 12;149(6):1309–1323. doi: 10.1083/jcb.149.6.1309

Figure 2.

Figure 2

MDCK cells overexpressing secreted MMPs display normal invasive and morphogenic activities. A, Western blots showing the relative expression levels of the identified MMPs in control (C) and transfected (T) MDCK cells. Brackets indicate the positions of the glycosylated and nonglycosylated forms of proMMP-1, proMMP-3, and proMMP-11, respectively, whereas asterisks indicate active glycosylated and nonglycosylated forms of MMP-3, or active forms of MMP-2 and MMP-11. B–I, After stimulation with SF/HGF for 12 d, the invasion patterns of control transfectants (B) and the clones overexpressing each of the indicated MMPs (C–I) were indistinguishable. Neither control nor MMP transfectants displayed invasive activity in the absence of SF/HGF (data not shown). Bar, 100 μm.