Table 4.
Electrophysiological Properties of Neurons
| Synaptic activity | |||||
|---|---|---|---|---|---|
| INa amplitude | Frequency | Amplitude | Range | Spiking activity | |
| nA | Hz | pA | pA | ||
| 4–5 d neuron | 0.20 ± 0.08 (7) | 0.03 ± 0.01 (7) | −27.7 ± 5.4 (7) | −6 to −52 (7) | – |
| 7–10 d neuron | 1.04 ± 0.21 (8) | 0.82 ± 0.13 (10) | −91.8 ± 4.8 (10) | −5.6 to −456.8 (10) | Yes (6) |
| +TTX | 0 (7) | 0.30 ± 0.1 (7) | −12.6 ± 0.5 (7) | −5.3 to −95.2 (7) | No (7) |
| +Bicuculline | – | 0.03 ± 0.01 (9) | −15± 1.7 (9) | −6 to −57.6 (9) | Yes (5) |
| +CNQX | – | 0.47 ± 0.17 (11) | −32.1 ± 2.5 (11) | −5 to −329.8 (11) | No (5) |
Data are expressed as mean ± SEM. Statistical significance was established by comparing all the conditions tested to their internal control, represented by 7–10 d neuron and using the Mann-Whitney statistical test. Treatments with TTX (1 μM), bicuculline (10 μM), and CNQX (10 μM) were performed for 24–72 h. Number in parentheses equals the number of independent experiments.