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Tumor reactivity of TIL 2098. Tumor reactivity of TIL 2098 as well as a PBMC sample obtained at 8 weeks following adoptive cell transfer (PBMC8w) was evaluated in an IFN-γ release assay. PBMC8w was cultured in 500 CU/mL IL-2 for 16 hours before assay. The tumor reactivity of TIL 2098 and PBMC8w cells was tested with autologous 2098 tumor cells, allogeneic HLA-A2 positive 624mel, 1088mel, 1907mel, 1909mel, and 2023mel tumor cells, and HLA-A2 negative 397mel and 888mel tumor cells.
