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. Author manuscript; available in PMC: 2008 Nov 9.
Published in final edited form as: Mol Cell. 2007 Nov 9;28(3):458–467. doi: 10.1016/j.molcel.2007.09.007

Figure 5. Model depicting two molecular contributions to release catalysis by RF1.

Figure 5

P-site bound tRNA carrying a tripeptide (colored circles) is protected in the absence of an A-site substrate by ribosomal RNA including the A and P loops (Schmeing et al., 2005b). RF1 (lavender) contributes to catalysis of peptide release by 1) “opening up” the ribosomal active site to allow solvent entry and 2) specific activation of a water molecule (red) controlled by the GGQ glutamine (Q).