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. 2000 Aug 7;150(3):97–100. doi: 10.1083/jcb.150.3.f97

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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A schematic of nodal region in longitudinal orientation. Three regions can be distinguished based on ultrastructure and molecular composition. The juxtaparanodal axon membrane contains high concentration of K⁺ channels. The adaxonal myelin membrane and paranodal loops (PNS only) contain MAG. The paranodal loops are connected to each other by adherens junctions that contain E-cadherin and β catenin and to the axon by septate-like junctions that contain caspr-1 and neurofascin 155. Na⁺ channels cluster in the nodal axolemma and bind to the skeletal protein ankyrin_G. Neurofascin 186 and NrCAM also bind ankyrin_G and may help target Na⁺ channels to the node.