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. 2000 Aug 7;150(3):567–580. doi: 10.1083/jcb.150.3.567

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Scheme for how p120ctn may regulate the activity of RhoA, Rac1, and Cdc42. p120ctn exists in an equilibrium between two states, bound to the juxtamembrane region of cadherins or free in the cytoplasm. When it is not associated with cadherins, p120ctn deceases RhoA activity and increases the activity of Cdc42 and Rac1. One possible means by which p120ctn may activate Cdc42 and Rac1 is via association with the exchange factor Vav2.