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. 2000 Aug 7;150(3):499–512. doi: 10.1083/jcb.150.3.499

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Proposed model describing the pathway of spindle pole positioning during embryonic cell division using the five MT-based motors: KRP₁₈₀, the COOH-terminal kinesin (Kinesin-C), cytoplasmic dynein, KRP₁₁₀, and KRP₁₇₀. Diagrams are shown for the proposed timing and mechanisms of action during (A) prophase/spindle assembly, (B) (pro)metaphase/spindle maintenance, and (C) anaphase B/spindle elongation. Colored arrows indicate the direction of force exerted by the motor of the same color.