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. 1998 Dec 28;143(7):1899–1918. doi: 10.1083/jcb.143.7.1899

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Microtubule dependence of the fast peripheral and central melanosome movements. (A) A dilute melanocyte before the addition of nocodazole. (B) Some of the fast centrifugal (left) and centripetal (right) movements that occurred over a 2-min period within the boxed area in A. (C) The same cell as in A, but 5 min after the addition of 16 μM nocodazole to the perfusion medium. (D) The paths for all of the melanosomes within the boxed area in C over the ensuing 1 min. (E) The lightly melanized cell also described in Fig. 3, before the addition of nocodazole. (F) Some of the fast central movements that occurred within the boxed area in E over a 1-min span. (G) The same cell as in E, but after treatment with nocodazole and incubation at 4°C, as described in the text. (H) The complete paths for all of the melanosomes within the boxed area in G over a 1-min time span (i.e., all 60 positions for each melanosome are shown). (I) The same cell as in G, but following perfusion for 30 min without nocodazole. (J) A portion of the fast centrifugal (left) and centripetal (right) movements that occurred over a 2-min period within the boxed area in I. Bars, 2.88 μm.