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. 2000 Sep 4;150(5):1085–1100. doi: 10.1083/jcb.150.5.1085

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The inability of BMP-2 expressing npmc to differentiate into osteogenic lineage. The npmc were isolated from a male mdx mouse and injected in the hind limb muscle of a female SCID mice. We have observed that npmc genetically engineered to express BMP-2 also leads to ectopic bone formation when injected in skeletal muscle. A, The FISH technique was used to identify the Y chromosome positive cells (donor cells) and revealed that the injected cells were located outside of the osteoid (B, arrow); a complete absence of Y chromosome positive cells was found within the newly formed osteoid (C, arrows). These cells were therefore incapable of differentiating into osteogenic lineage in vivo. Bar: (A) 100 μm; (B and C) 50 μm.