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In vitro analysis of neuronal migration. Migration of tatau+/+map1b+/+ (A) and tau−/−map1b−/− (B) cerebellar granule cells from reaggregate cell clusters after 24 h of culture. (C) Mean ± SEM of the number of migrating cerebellar granule cells and their distance of migration from the reaggregate cell cluster in tau+/+map1b+/+ and tau−/−map1b−/− mice after 24 h. Three animals of each genotype were used, and 35 tau+/+ map1b+/+ and 33 tau−/−map1b−/− clusters were examined. Bar, 100 μm.
