Table 6.
Effect of tau and map1b Mutation on Neurite Development in Cultured Hippocampal Neurons
| Neurite length | No. of neurites | n | ||
|---|---|---|---|---|
| Axon | Minor process | |||
| μm | ||||
| tau+/+map1b+/+ | 172.5 ± 10.8 | 37.8 ± 2.7 | 6.2 ± 0.1 | 6 |
| tau−/−map1b+/+ | 167.5 ± 9.9 | 36.9 ± 2.3 | 6.0 ± 0.1 | 4 |
| tau+/+map1b−/− | 135.8 ± 4.4 | 25.2 ± 1.5 | 5.3 ± 0.4 | 4 |
| tau−/−map1b−/− | 62.6 ± 8.0 | 22.0 ± 0.9 | 5.7 ± 0.4 | 5 |
Values in each hippocampal neuron were measured directly on immunofluorescence micrographs of the cells stained using a monoclonal antibody against tubulin. n, Number of animals examined. 30 cells in stage 3 per animal were analyzed. The means ± SEM are shown.