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. 2000 Sep 4;150(5):1177–1188. doi: 10.1083/jcb.150.5.1177

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© 2000 The Rockefeller University Press

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Immunohistochemical analysis reveals a correlation of ST3 expression with ECM remodeling in the X. laevis small intestine during metamorphosis. (A) No ST3 could be detected at stage 58, when the larval epithelium (indicated by E) degeneration has yet to take place. CT, connective tissue. (B) ST3 protein could be detected in fibroblasts (arrow) by stage 60. M, muscle. (C) Fibroblasts/fibroblast-like cells expressing ST3 (arrowheads) were present adjacent to the metamorphosing epithelium at stage 61. Ty, typhlosole. (D and E) ST3-expressing fibroblasts (arrows) near the degenerating larval epithelium (LE) and the adult epithelial primordia (AE) at stage 61. Note that the labeling in the larval epithelium was due to nonspecific binding by the fragments of dying cells. The adult epithelium was protruding into the connective tissue. (F) Relatively few cells with weak ST3 levels (arrow) could be detected in the crest of intestinal folds (Fo) at stage 63. (G) No ST3 expression could be detected at stage 65. (H) Electron micrograph of the epithelial–connective tissue interface at stage 58 showing a thin but continuous basal lamina (BL). (I) Electron micrograph of the epithelial–connective tissue interface showing a multiply folded basal lamina at stage 61. Bars: (A–G) 20 μm; (H and I) 0.5 μm.