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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Anal Biochem. 2007 Sep 1;372(1):21–31. doi: 10.1016/j.ab.2007.08.034

Table 1. DNA-uracil concentrations reported in the literature.

A broad range of DNA-uracil concentrations from fresh or cultured cells has been reported by different researchers. Some of these concentrations are shown in the table above. “U” = uracil, “deficiency” = type of vitamin deficiency investigated for association with increased DNA-uracil.

pg U/μg DNA 1000 U/
diploid cell
Reference min max Min max organism /
cell type / deficiency
Mashiyama et al. 2004 (24) 0.33 6.35 10 195 human / cultured primary
lymphocytes / folate
Choi et al. 2003 (31) 3.89 5.09 119 156 rat / colon cells / folate
Ren et al. 2002 (30) 0.20 1.94 6 60 human / lymphocytes /
folate
Crott et al. 2001 (29) 0.76 4.84 23 149 human / cultured primary
lymphocytes / folate
Koury et al. 1997 (28) 0.43 1.77 13 54 mouse / erythroblasts /
folate
Blount et al. 1997 (1) 1.66 129.02 51 4000 Human / cells from
whole blood / folate
Ramsahoye et al. 1996 (27) 41.41 42.93 1271 1318 human /
bone marrow cells /
cobalamin
Blount et al. 1994 (26) 0.70 3.00 21 92 rat / hepatocytes / folate