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. 2000 Aug 21;150(4):887–894. doi: 10.1083/jcb.150.4.887

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The expression of caspase-12. (A) A Western blot of caspase-12. Anti–caspase-1 and antitubulin antibodies were used as controls. Caspase-12 is constitutively expressed in postnatal day 4 mouse tissues. (B) Caspase-12 localizes on the outer membrane of the ER. IP3R, a transmembrane protein, was readily digested by trypsin as that of caspase-12, whereas ER lumenal proteins, grp78, grp94, and calreticulin were protected against trypsin digestion. ut, untreated.